LUMC is a world-class academic hospital with a strong focus on scientific research (www.LUMC.NL). The LUMC Dept. of Medical Microbiology has coordinated and participated in many EC-funded research projects on (emerging) RNA viruses and antiviral drug discovery, has hosted ESRs from Marie Curie ETNs EUVIRNA and VACTRAIN and is currently hosting ESRs from ETN ANTIVIRALS. The Molecular Virology laboratory of the Department of Medical Microbiology is embedded in the LUMC Center of Infectious Diseases, and the Immunity, Infection and Tolerance research profile. The lab includes about 7 PhD candidates, several postdocs and technicians and numerous undergraduate students. The group focuses on the fundamentals of RNA virus replication (predominantly coronaviruses, arteriviruses, alphaviruses and flaviviruses) and the interaction with their hosts, but is also engaged in more translational research into novel vaccine options and antiviral therapeutics.
Prof. Eric J. Snijder heads the Molecular Virology team and is an expert on the molecular virology of RNA viruses. His track record includes seminal studies on viral replicative enzymes, the design and use of reverse genetic systems for +RNA viruses, and studies of the replication organelles of these viruses using state-of-the art electron microscopy and -tomography.
Dr. Kikkert’s research focuses on antiviral innate immunity and viral immune evasion in the context of RNA virus infections. Her group is currently studying the role of viral deubiquitinating proteases in immune evasion and virus pathology, as well as other interactions of RNA viruses with the ubiquitin-regulated innate immune response.