Primary supervisor: Dr. K. Pardalli, AstraZeneca, Gothenburg, Sweden
Title: Elucidating the effects of IFNs in the plasticity of innate immune cells
Collaborators: Prof. A. Santoni, Institute Pasteur-Rome, Italy; Dr. B. van den Hoogen, ErasmusMC, Rotterdam, the Netherlands
AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. We’re proud to have a unique workplace culture that inspires innovation and collaboration. We believe in the potential of our people and you’ll develop beyond what you thought possible. The new R&D BioPharmaceuticals organisation brings together research and development teams, from discovery through to late-stage development for Cardiovascular, Renal & Metabolic (CVRM), Respiratory, Inflammatory and Autoimmune (RIA) therapy areas, and opportunistically for Microbial Sciences and Neuroscience. You will join an agile environment, with a culture that is science and patient-focused. AZ’s Early RIA mission is to understand disease mechanisms at the molecular level, identify the most effective target and the right patient population, and close the gap between bench science and bedside clinical practice.
Karolinska Institutet is one of the world´s leading medical universities. Its mission is to contribute to the improvement of human health through research and education. Since 1901 the Nobel Assembly at Karolinska Institutet has selected the Nobel laureates in Physiology or Medicine. It accounts for over 40 % of the medical academic research conducted in Sweden and offers the country´s broadest range of education in medicine and health sciences. The Mjösberg group at KI studies the development, regulation and function of a particular immune cell, innate lymphoid cells (ILCs), in humans, and how these cells contribute to pathology in mucosal organs such as the lung and gut. The studies are translational as they involve advanced basic molecular and cellular immunological investigations of precious human tissue samples to discover novel disease mechanisms and therapy targets in inflammatory bowel disease, colorectal cancer, allergy and asthma. The group is internationally recognized as a leader in the field through several high impact publications in recent years (Nat Immunol 2016, JACI 2018, JACI 2018). The student will be a part of the Center for Infectious Medicine (CIM), Karolinska Institutet, which is a nationally leading and internationally competitive center for human translational immunology and infectious diseases research. The center consists of approximately 25 graduate students and 20 postdocs organized around 17 independent research groups, which has fostered many young and competitive researchers.
Main Duties and Responsibilities
This project aims in understanding the mechanism by which virally induced factors such as IFNs and alarmins affect the plasticity and function of ILCs with particular focus on the role for eicosanoid production in ILCs. Furthermore, we want to elucidate whether ILCs can be infected by respiratory viruses, and the effect this might have in the phenotype, plasticity and metabolic signature of ILCs. In addition, this project aims to determine alterations in ILC frequency and function during novel biological treatment of asthma patients, potentially providing predictive tools for therapeutic response. Increased understanding of ILCs in asthma can help us identify novel targeting strategies to modulate the immunopathology of respiratory diseases and result in novel treatments that can not only address symptoms but modify and cure the underlying cause of disease.
We are looking for a motivated student with a strong commitment to basic and/or translational research, who:
- Is eligible for MSCA-ETN funding (see eligibility criteria).
- Has a degree in cell biology, molecular/cell biology, biomedical sciences, immunology or related disciplines.
- Has excellent experimental and analytical skills in cellular and molecular biology
- Possesses hands on experience working with human immune cells, and basic cellular and molecular biology methods
- Strong scientific background and interest in immunology and/or cell metabolism
- Excellent organizational, communication and team-player skills with strong English knowledge in both oral and writing.
- Enthusiastic, highly self-motivated and with the ability to function independently
Type of Contract: Temporary (36 months)
Status: Full-time (40 hours/week)
Specific Requirements for the project
Applicants need to fully comply with three eligibility criteria
- Early-stage researchers (ESR) are those who, at the time of recruitment by the host, are in the first four years (full-time equivalent) of their research careers. This is measured from the date when they obtained the degree which formally entitles them to embark on a doctorate, either in the country in which the degree was obtained or in the country in which the research training is provided, irrespective of whether or not a doctorate was envisaged. Please note that applicants cannot already hold a PhD at the time of recruitment.
- Conditions of international mobility of researchers: Researchers are required to undertake transnational mobility (i.e. move from one country to another) when taking up the appointment. Researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of their host organization for more than 12 months in the 3 years immediately prior to their recruitment. Short stays, such as holidays, are not taken into account.
- English language: Network ESRs must demonstrate that their ability to understand and express themselves in both written and spoken English is sufficiently high for them to derive the full benefit from the network training
Organisation/Institute Contact Data
Company: AstraZeneca, Gothenburg, Sweden
We are interviewing continuously, welcome with your application already today and no later than September 15th, 2019.
For more information about life in Gothenburg visit www.movetogothenburg.com
The Marie Skłodowska-Curie Actions offer attractive salary and working conditions. The successful candidates will receive a salary in accordance with the national legislation of the recruiting institution and the Marie Skłodowska-Curie Actions regulations for early stage researchers. Exact salary will be confirmed upon appointment
In addition to their individual scientific projects, all ESR will benefit from further continuing education, which includes scientific skills courses, transferable skills courses, as well as active participation in workshops and conferences and secondments to partner labs.
Each ESR will be hired for 3 years, full time.
The European INITIATE training network wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.