Expired on: Jul 15, 2019

Primary supervisor: Dr. B. van den Hoogen, ErasmusMC, Rotterdam, The Netherlands
Title: To determine the role of Pneumovirus infection in regulation of MAVS signalling and its effect on immune- and metabolic pathways.
Collaborators: Prof. A. Bowie, Trinity College Dublin, Ireland; Dr. K. Pardalli, AstraZeneca, Gothenburg, Sweden.

For respiratory viruses such as the Human Metapneumovirus (HMPV) , a member of the Pneumoviridae family, little is known about their interaction with the immunometabolism pathways. Elucidating knowledge on this interaction could lead to a rational design of antiviral therapies. Data so far, suggest that the M22 protein of HMPV is responsible for subverting the innate immune response by interfering withs MAVS signlalling , but other proteins and other pathways might also be involved in the mechanism. MAVS not only plays a pivotal role in the induction of antiviral and inflammatory pathways, but is also involved in the coordination of apoptotic and metabolic pathways.
Using our expertise on the molecular virology of HMPV, and a wide set of molecular, biochemical, virological and immunological techniques, ESR7 will determine the role of the Pneumovirus M2.2 protein, as well as other viral proteins, in the interaction with innate immune- and metabolic pathways, with a focus on MAVS signalling. Cells knocked-down cellular factors of interest, made with CRISPr/Cas technology, will be used to further analyse the interaction and the effect on viral replication and immune-and metabolic profiles of infected cells.
In collaboration with Prof. A. Bowie at Trinity College in Dublin, ESR7 will determine the interaction of (specific proteins) of Pneumoviruses with the innate immune, inflammatory and metabolic pathways in more detail. In collaboration with Dr. K. Pardalli at AstraZeneca in Sweden, ESR7 will determine whether pneumovirus inflammasome activation is altered in primary human lung epithelial cells from asthma and/or COPD patients.

Type of Contract: Temporary (48 months)
Status: Full-time (38 hours/week)
Specific Requirements for the project
Prospective PhD candidates have a MSc in Biology, Biomedical Sciences, or a related field of study. They have strong knowledge of infectious diseases and the immune system and are highly motivated to perform ground-breaking research at the international forefront at the cross-roads of these areas.
Organisation/Institute Contact Data
Research lab: Dept. of Viroscience, ErasmusMC, Rotterdam, The Netherlands
Contact Primary Supervisor: Dr. B. van den Hoogen; b.vandenhoogen@erasmusmc.nl
Website: www6.erasmusmc.nl/viroscience/research/researchers/vandenhoogen/

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